Acromegaly

Acromegaly is a rare chronic disorder characterised by

excessive growth hormone (GH)

production in adults, typically due to a

pituitary adenoma

. This leads to insidious enlargement of bones and soft tissues, particularly in the hands, feet, face, and skin, resulting in distinctive physical changes and multisystem complications if untreated.

What is acromegaly?

Acromegaly arises from

hypersecretion of GH

after epiphyseal closure in adulthood, distinguishing it from gigantism which occurs pre-puberty. The excess GH stimulates

insulin-like growth factor-1 (IGF-1)

production in the liver, driving acral and facial bone overgrowth, visceromegaly, and metabolic derangements. Approximately 95% of cases stem from benign

pituitary adenomas

(somatotrophinomas), with rare causes including ectopic GH-releasing hormone (GHRH) secretion or pituitary hyperplasia.

The condition affects 3-4 individuals per million annually, with mean diagnosis age around 45 years and slight male predominance. Untreated acromegaly reduces life expectancy by 10 years due to cardiovascular disease, respiratory failure, and malignancy.

Who gets acromegaly?

Acromegaly typically manifests in

middle-aged adults

(30-60 years), with equal male-female distribution in some cohorts but male predominance noted in others. No strong ethnic or geographic predisposition exists, though delayed diagnosis (average 7-10 years) occurs due to subtle progression.

Risk factors include:

• Underlying

  pituitary adenoma

  (most common).
• Genetic syndromes like

  multiple endocrine neoplasia type 1 (MEN1)

  ,

  carney complex

  , or

  familial isolated pituitary adenoma

  (5-10% of cases).
• Rare ectopic GHRH production from pancreatic/bronchial tumours.

What causes acromegaly?

Over 95% of acromegaly results from

monoclonal pituitary somatotroph adenomas

. These tumours autonomously secrete GH independent of hypothalamic regulation. Microadenomas (<10mm) cause ~15% of cases; macroadenomas (>10mm) cause 85%, often with mass effects like visual field defects.

Pathophysiology involves:

• GH hypersecretion → elevated IGF-1 → bone/soft tissue hypertrophy.
• Local tumour expansion → compression of optic chiasm, cavernous sinus invasion.
• Cosecretion of prolactin (25-50% of tumours) or rarely TSH/ACTH.

Rare causes (<1%):

• Ectopic GHRH

from neuroendocrine tumours → pituitary hyperplasia.

• Genetic mutations (AIP gene, GNAS mutations).

What are the clinical features of acromegaly?

Skin features

Characteristic

cutaneous manifestations

often precede systemic symptoms:

• Coarse facial features: frontal bossing, deepened nasolabial folds, macroglossia, prognathism, widened dental spaces.
• Acral enlargement: increased ring/shoe size, thickened digits.
• Skin changes: thickened, oily skin; hyperhidrosis (80%); malodorous sweat; acanthosis nigricans; skin tags (75%).
• Acrochordons and

  dermal hyperplasia

  common.

Systemic features

System	Manifestations
Cardiovascular	Left ventricular hypertrophy, hypertension (35%), cardiomyopathy, arrhythmias
Endocrine	Diabetes mellitus (25-50%), insulin resistance, menstrual irregularities, hypopituitarism (30%)
Musculoskeletal	Osteoarthritis, joint pain, carpal tunnel syndrome (30-60%), vertebral fractures
Respiratory	Sleep apnoea (60%), upper airway obstruction from macroglossia
Neoplastic	Colon polyps/cancer risk ↑2-7x, thyroid nodules

How is acromegaly diagnosed?

Diagnosis combines

clinical suspicion

with

biochemical confirmation

and

imaging

:

1. Biochemical testing:
   • Age-adjusted

     IGF-1

     (gold standard screening).
   • **Oral glucose tolerance test (OGTT)**: failure of GH suppression <1μg/L diagnostic.
   • Random GH unreliable due to pulsatility.
2. Imaging: pituitary MRI (95% sensitivity).
3. Visual fields if macroadenoma suspected.

Normal ranges: IGF-1 varies by age/sex; OGTT nadir <0.4μg/L excludes diagnosis.

What is the treatment for acromegaly?

Treatment aims to normalise

GH/IGF-1

, reduce tumour volume, preserve pituitary function, and reverse complications.

Multimodal therapy

combines surgery, medical therapy, and radiotherapy. No single approach suffices for all patients.

Surgery

**Transsphenoidal adenomectomy** is first-line, achieving biochemical remission in 50-80% microadenomas and 20-50% macroadenomas. Endoscopic techniques improve outcomes. Rapid symptom relief occurs within days.

Medical therapy

Three classes used as primary, adjuvant, or salvage therapy:

• Somatostatin receptor ligands (SRLs) (first-line medical): Octreotide LAR, lanreotide autogel (monthly IM), pasireotide. Normalise IGF-1 in 50-65%; tumour shrinkage 20-50%. FDA-approved oral octreotide (Mycapssa) for responders.
• GH receptor antagonist: Pegvisomant (Somavert®) daily SC. Normalises IGF-1 in 90%+ but no antitumour effect. New oral paltusotine approved.
• Dopamine agonists: Cabergoline (licensed off-label). Effective in 10-20%, useful for mild disease/prolactin cosecretion.

Radiotherapy

Reserved for surgical/medical failure. Fractionated external beam (4-6 weeks) achieves control in 50-70% over 5-10 years but risks hypopituitarism (50-80%). Stereotactic radiosurgery for residuals.

Acromegaly in skin of colour

Skin findings remain consistent across ethnicities, though

hyperpigmentation

from acanthosis nigricans may be more prominent in darker skin types. Hyperhidrosis and skin tags universally prevalent. Diagnostic delays similar across groups.

Related conditions

• Pseudocromegaly: Ectopic acromegaly, McCune-Albright syndrome.
• Gigantism: Prepubertal GH excess.
• Cushing disease,

  primary hypogonadism

  (overlapping features).

Frequently asked questions in acromegaly

What is the most common cause of acromegaly?

Pituitary adenoma (95%+), specifically somatotroph adenomas secreting excess GH.

How do you diagnose acromegaly?

Elevated age-matched IGF-1 plus failure of GH suppression <1μg/L on OGTT, confirmed by pituitary MRI.

What does the face look like in acromegaly?

Coarse features: prominent supraorbital ridges, broad nose, prognathism, macroglossia, widened teeth spacing.

Is acromegaly curable?

Biochemical control achievable in 60-80% with multimodal therapy; surgical cure in ~50% microadenomas.

What is the prognosis for treated acromegaly?

Normalised GH/IGF-1 restores life expectancy; untreated mortality increased 2-3x from cardiovascular/respiratory disease.

Activity

Monitor GH/IGF-1 every 3-6 months initially, then annually. Colonoscopy screening q5-10y. Cardiovascular risk management essential.