Dicycloverine Guide: Dosage, Uses & Side Effects

Comprehensive guide to Dicycloverine: uses, dosage, side effects, and key considerations for treating IBS symptoms effectively.

By Sneha Tete, Integrated MA, Certified Relationship Coach

Created on Jan 13, 2026

Comprehensive guide to Dicycloverine: uses, dosage, side effects, and key considerations for treating IBS symptoms effectively.

Dicycloverine, also known as dicyclomine and sold under brand names like Bentyl, is an anticholinergic antispasmodic medication primarily used to treat intestinal spasms associated with irritable bowel syndrome (IBS).

About Dicycloverine

Dicycloverine belongs to a class of drugs called antispasmodics, which work by relaxing smooth muscles in the gastrointestinal tract. It blocks the action of acetylcholine on muscarinic receptors, reducing muscle contractions, cramps, pain, bloating, and discomfort caused by spasms in the stomach and intestines. This medication is particularly effective for managing symptoms of hypermotility in IBS, where the intestines contract abnormally.

Approved for medical use in the United States in 1950, dicycloverine remains a commonly prescribed treatment, ranking as the 192nd most prescribed medication in 2023 with over 2 million prescriptions. It is available as tablets, capsules, syrups, and injectable forms, typically taken orally four times daily. While its exact mechanism is not fully understood, it selectively antagonizes M1 muscarinic receptors in the gut, providing relief without significantly affecting other systems at therapeutic doses.

Historically, it was used for infant colic and even included in morning sickness formulations like Bendectin until 1976, but current evidence does not support these applications due to lack of efficacy and safety risks.

Key facts

Drug group: Antispasmodic (anticholinergic).
Common brands: Bentyl, generic dicycloverine hydrochloride.
Available doses: 10mg and 20mg tablets/capsules; syrup; injection (not IV).
Treatment for: IBS symptoms like cramps, pain, bloating, and diarrhea-predominant IBS.
Duration: Short-term relief; not curative. Effects last 4-6 hours, requiring multiple daily doses.
Prescription status: Prescription-only in most countries.
Age restrictions: Approved for adults and children over 12; caution or avoidance in younger children.

About irritable bowel syndrome (IBS)

Irritable bowel syndrome is a common functional gastrointestinal disorder affecting 10-15% of the population, characterized by abdominal pain, bloating, altered bowel habits (diarrhea, constipation, or both), and spasms without structural abnormalities. IBS significantly impacts quality of life, with symptoms often triggered by stress, diet, or gut motility issues.

Dicycloverine targets the hypermotility aspect, particularly in IBS with diarrhea (IBS-D), as recommended in clinical guidelines since 2016 as a first-line antispasmodic therapy. It does not address underlying causes but provides symptomatic relief by relaxing intestinal smooth muscles.

How antispasmodics work for IBS

Antispasmodics like dicycloverine inhibit parasympathetic nerve signals that cause excessive gut contractions. By antagonizing muscarinic M1, M3, and M2 receptors, it decreases intestinal motility and secretions, alleviating spasms. This leads to reduced pain and bloating. Unlike opioids, it does not cause dependence but carries anticholinergic risks.

Clinical evidence supports its use in functional bowel disorders, though some guidelines note limited high-quality trials, making it a targeted rather than universal first-line option.

When not to take Dicycloverine (contraindications)

Dicycloverine is contraindicated in several conditions due to its anticholinergic effects, which can worsen obstructions or glaucoma:

Obstructive gastrointestinal or urinary tract conditions (e.g., bowel obstruction).
Severe ulcerative colitis.
Glaucoma (especially angle-closure).
Myasthenia gravis.
Unstable cardiac conditions, hiatal hernia, reflux esophagitis.
Acute gastrointestinal bleeding.
Infants and children under 2 years, or for colic (risk of convulsions, breathing issues).
Prostatic enlargement or urinary retention.

Pregnancy appears safe (Category B), but breastfeeding is not recommended due to potential infant effects.

Taking Dicycloverine with other medicines and herbal supplements

Dicycloverine interacts with other anticholinergics, amplifying side effects like dry mouth or constipation. Avoid with:

Other antispasmodics, antidepressants (e.g., amitriptyline), antipsychotics.
MAO inhibitors (risk of hypertension).
Alcohol (increases drowsiness).

It may reduce absorption of sustained-release drugs. Inform your doctor of all medications.

Common questions about Dicycloverine

How and when to take or use Dicycloverine tablets/capsules/syrup

Take as prescribed, usually 10-20mg orally 4 times daily, 30 minutes before meals to maximize absorption and minimize food interference. Swallow tablets whole with water; syrup for those who can’t swallow pills. Do not exceed 80mg/day. Injection: 20mg IM 4 times daily for severe cases.

Adult dosage

Standard: 20mg 4 times daily; start at 10mg if sensitive.

Children’s dosage

Age	Dose
12+ years	10mg 3 times daily
2-11 years	10mg 3 times daily (under medical supervision)

How to cope with side effects of Dicycloverine tablets/capsules/syrup

Dry mouth: Sip water, chew sugar-free gum.
Dizziness/blurred vision: Avoid driving; rest.
Constipation: Increase fiber/water; laxatives if needed.
Drowsiness: Take at bedtime if possible.

Most resolve with time or dose reduction.

Pregnancy and breastfeeding while taking Dicycloverine tablets/capsules/syrup

Use in pregnancy is generally safe based on available data, but consult a doctor. Avoid breastfeeding as it passes into milk and may cause infant anticholinergic effects.

Other medicines, foods and Dicycloverine tablets/capsules/syrup

No major food interactions, but take before meals. Contains lactose/sucrose in some formulations—caution in intolerances.

Side effects of Dicycloverine tablets/capsules/syrup

Common anticholinergic effects affect up to 1 in 10 users:

Dry mouth, blurred vision, dizziness, drowsiness.
Constipation, nausea, headache.
Lightheadedness, weakness.

Serious (rare, seek immediate help):

Psychosis, confusion, hallucinations (especially elderly).
Heart palpitations, urinary retention, heat intolerance.
Seizures, severe constipation, breathing difficulties.

Overdose: Flushing, hot dry skin, delirium—seek emergency care.

Frequently Asked Questions (FAQs)

What is Dicycloverine used for?

Primarily for relieving IBS symptoms like cramps and spasms by relaxing gut muscles.

How quickly does Dicycloverine work?

Relief often within 1-2 hours; full effects with regular dosing.

Can I drink alcohol with Dicycloverine?

No, it increases drowsiness and dizziness.

Is Dicycloverine safe for long-term use?

For short-term symptom relief; long-term use requires monitoring for side effects.

Does Dicycloverine cause weight gain?

Not commonly; constipation may indirectly affect it.