Mebeverine (Colofac): Uses, Dosage & Side Effects
Complete guide to mebeverine: dosage, uses, side effects, and storage information.
About Mebeverine
Mebeverine is an antispasmodic medicine used to relieve bloating and crampy pain in the lower abdomen. These symptoms are commonly associated with irritable bowel syndrome (IBS) and other gastrointestinal conditions. The medication works by relaxing the muscles in the wall of your intestines, which helps ease pain and cramps.
Mebeverine is available under several brand names, including Colofac® and Aurobeverine®. It can be obtained either on prescription or purchased from a pharmacy without a prescription in some cases. The medicine comes in multiple forms to suit different patient preferences and needs.
| Type of Medicine | Antispasmodic |
|---|---|
| Used For | Relief of gastrointestinal cramps and symptoms in adults |
| Brand Names | Colofac®, Colofac IBS®, Aurobeverine® |
| Available Forms | Tablets, modified-release capsules, and oral liquid medicine |
How Mebeverine Works
Mebeverine functions by targeting the smooth muscles within the gastrointestinal tract. The exact mechanism of action is not completely understood; however, research suggests that mebeverine may work directly on smooth muscle, potentially having an anaesthetic effect and affecting calcium channels. Unlike some other antispasmodic medications, mebeverine does not produce systemic anticholinergic side effects, making it a safer option for many patients.
This antispasmodic action helps reduce the muscle contractions and spasms that cause discomfort, allowing patients to experience relief from abdominal pain, cramping, bloating, and related symptoms associated with IBS.
Before Taking Mebeverine
Before you start taking mebeverine, it is important to inform your healthcare provider about certain medical conditions and medications. You should not take mebeverine if:
- You have severe constipation or feel that your bowel is not working properly
- You are taking any other medicines, including those available without prescription, herbal medicines, and complementary medicines
- You have ever had an allergic reaction to a medicine
Always read the manufacturer’s printed information leaflet that comes inside the medicine pack before starting treatment, as it provides detailed information about mebeverine and potential side effects you may experience.
How to Take Mebeverine
The dosage and administration of mebeverine depend on the form you have been prescribed. It is essential to take mebeverine exactly as directed on the label to ensure maximum effectiveness.
Tablet Form (135 mg)
The usual dose for tablets is one tablet three times daily. Most people find it beneficial to take the doses approximately 20 minutes before the three main meals of the day. Swallow the tablets with a small glassful of water, and importantly, do not chew the tablets as they have an unpleasant taste.
Liquid Medicine (50 mg in 5 ml)
If you have been prescribed the liquid formulation, the dose information will be printed on the label of your specific pack. Take the doses approximately 20 minutes before your three main meals of the day, if possible. This timing helps optimize the medication’s effectiveness in preventing and managing symptoms.
Modified-Release Capsules (200 mg Colofac® MR)
For modified-release capsules, the recommended dosage is one capsule twice daily – one in the morning and one in the evening. Try to take the capsules about 20 minutes before a meal and swallow each dose with a small glassful of water (at least 100 ml). Critically, do not chew or open the capsules, as this would damage the coating that controls how the mebeverine is released into your system.
Missed Doses
If you forget to take a dose, do not take two doses together to make up for the missed dose – simply continue with the next dose when it is due.
Getting the Most from Your Treatment
It is generally recommended that you take mebeverine only when necessary. This approach involves starting the medication when your symptoms flare up and continuing until you feel better, then stopping when your symptoms settle down, which typically occurs within a week or two.
However, if you have purchased mebeverine for IBS and your symptoms have not improved within two weeks of taking it, you should see your doctor for further advice, even if you have previously been diagnosed with the condition. Similarly, if you develop any new symptoms, if your symptoms worsen, or if your symptoms have not improved within two weeks, make an appointment with your doctor for additional guidance.
Can Mebeverine Cause Problems?
While mebeverine is generally well-tolerated, like all medicines, it can cause unwanted side effects, although not everyone experiences them. The good news is that side effects are rare and any that do occur are usually mild and rarely cause significant problems.
Common Side Effects
Most patients tolerate mebeverine without experiencing troublesome side effects. However, a full list of possible side effects can be found in the manufacturer’s information leaflet supplied with your medicine.
Allergic Reactions
Although uncommon, a few people have developed an allergic-type reaction to mebeverine. Symptoms may include an itchy rash or swelling around the face. Although these symptoms occur rarely, if you develop this type of reaction, you should let your doctor know immediately, or alternatively, go to the accident and emergency department of your local hospital.
Rare Adverse Effects
On highly rare occasions, mebeverine can cause drug-induced acute angle closure glaucoma. Additionally, in a urine drug-screening test, mebeverine can affect a false positive result for amphetamines. If you are undergoing any medical testing, inform your healthcare provider that you are taking mebeverine.
How to Store Mebeverine
Proper storage of mebeverine is important to maintain its effectiveness and safety. Always store mebeverine according to the instructions provided on the package. Generally, medicines should be stored in a cool, dry place away from direct sunlight and heat. Keep mebeverine out of the reach of children and away from pets. Do not use the medicine after the expiry date shown on the packaging. If you have any unused mebeverine, do not dispose of it through household waste; instead, take it to a pharmacy where it can be disposed of safely and appropriately.
Important Information About All Medicines
Before taking any medicine, including mebeverine, ensure you understand how it should be used and what to expect. Read all information provided by your pharmacist or healthcare provider carefully. If you have questions or concerns about mebeverine or any other medication, do not hesitate to ask your doctor or pharmacist for clarification.
Keep track of all medicines you are taking, and inform healthcare providers about all medications, supplements, and herbal products before starting any new treatment. This helps prevent potentially harmful drug interactions and ensures you receive the most appropriate care.
Frequently Asked Questions
Q: How quickly does mebeverine work?
A: Mebeverine typically begins to work within approximately 20 minutes to an hour after taking it, which is why it is recommended to take doses about 20 minutes before meals.
Q: Can I take mebeverine long-term?
A: Mebeverine is generally recommended for use when symptoms flare up rather than as a continuous long-term medication. However, your doctor can provide personalized advice based on your specific condition.
Q: Is mebeverine safe during pregnancy?
A: Before taking mebeverine during pregnancy, consult with your healthcare provider or pharmacist to ensure it is appropriate for your situation.
Q: Can I drink alcohol while taking mebeverine?
A: There are no known interactions between mebeverine and alcohol; however, it is always best to consult your healthcare provider or pharmacist about alcohol consumption while taking any medication.
Q: What should I do if I experience an allergic reaction?
A: If you develop signs of an allergic reaction such as rashes, swelling around the face, or difficulty breathing, contact your doctor immediately or visit the accident and emergency department of your local hospital.
Q: Can mebeverine be used in children?
A: Mebeverine is primarily used in adults for the relief of gastrointestinal symptoms. Always consult your healthcare provider before giving any medication to children.
Q: What is the difference between regular and modified-release mebeverine?
A: Modified-release capsules (Colofac® MR) release the medication gradually throughout the day, requiring only twice-daily dosing, whereas regular tablets typically require three times daily dosing.
References
- Mebeverine – Colofac — Patient.info. 2024. https://patient.info/medicine/mebeverine-colofac-aurobeverine
- COLOFAC® – Mebeverine hydrochloride Tablets 135 mg — Medsafe. 2024. https://www.medsafe.govt.nz/consumers/cmi/c/colofac.pdf
- Mebeverine — Wikipedia. 2024. https://en.wikipedia.org/wiki/Mebeverine
- Mebeverine: Uses, Interactions, Mechanism of Action — DrugBank. 2024. https://go.drugbank.com/drugs/DB12554
- Mebeverine hydrochloride for intestinal spasm — Medicines for Children. 2024. https://www.medicinesforchildren.org.uk/medicines/mebeverine-hydrochloride-for-intestinal-spasm/
- Mebeverine: a medicine to treat muscle spasms — NHS. 2024. https://www.nhs.uk/medicines/mebeverine/
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