Piroxicam Gel: What To Know About Uses And Side Effects
Effective topical pain relief with piroxicam gel for arthritis, sprains, and backache.

About Piroxicam Gel
Piroxicam gel is a topical non-steroidal anti-inflammatory drug (NSAID) commonly known by its brand name Feldene. It is applied directly to the skin to provide targeted pain relief and reduce inflammation in affected areas. Unlike oral medications that affect the entire body, piroxicam gel works locally where you apply it, making it an effective treatment option for various painful conditions.
| Type of Medicine | A non-steroidal anti-inflammatory skin gel |
|---|---|
| Used for | Treating pain and swelling due to strains, sprains, backache, or arthritis |
| Also called | Feldene® |
| Available as | Skin gel |
Piroxicam gel is a medicine classified as a non-steroidal anti-inflammatory drug, often referred to as an NSAID or simply an ‘anti-inflammatory.’ The active ingredient, piroxicam, prevents the production of natural chemicals in your body that cause pain and inflammation. When applied topically to the skin, it absorbs into deeper tissue layers where inflammation is present, such as muscles and joints, providing localized relief.
What is Piroxicam Gel Used For?
Piroxicam gel is commonly prescribed for a variety of painful and inflammatory conditions. Healthcare providers recommend it particularly for adults experiencing localized pain and swelling. The following conditions are frequently treated with piroxicam gel:
- Osteoarthritis and rheumatoid arthritis
- Joint pain and inflammatory diseases
- Gout
- Sports injuries, including strains and sprains
- Backache and muscular pain
- Rheumatism
The gel is particularly effective for conditions involving inflammation or swelling in localized areas. If you are experiencing other types of pain, such as migraines, sore throats, or toothaches, paracetamol is generally considered a more appropriate treatment option.
How Piroxicam Gel Works
Piroxicam works through a specific mechanism of action that targets the root cause of pain and inflammation. As an NSAID, it blocks the production of prostaglandins, which are natural chemicals in the body responsible for causing pain, inflammation, and swelling. By inhibiting these substances, piroxicam effectively reduces discomfort and swelling in the affected area.
When applied to the skin as a gel, piroxicam is absorbed through the skin barrier and penetrates deeper into the underlying tissues where inflammation occurs, such as muscles, joints, and connective tissues. This localized action means the medication concentrates where you need it most, rather than circulating throughout your entire body. As a result, the total amount of piroxicam in your bloodstream remains low, which significantly reduces the risk of systemic side effects that can occur with oral NSAIDs.
Before Using Piroxicam Gel
Before starting treatment with piroxicam gel, it is essential that your doctor knows about your medical history and current health status to ensure this is the right treatment for you. Inform your healthcare provider if any of the following apply to you:
- You are pregnant or breastfeeding
- You have asthma or any other allergic disorder
- You have a skin condition such as eczema or dermatitis
- You have ever had an allergic reaction to a non-steroidal painkiller (such as aspirin, ibuprofen, diclofenac, or indometacin)
- You have ever had an allergic reaction to any other medicine
Piroxicam gel is prescribed for adults and is not generally suitable for use by children. Your doctor will assess whether this medication is appropriate for your specific condition and medical history before prescribing it.
How to Use Piroxicam Gel
Proper application of piroxicam gel is important to ensure maximum effectiveness and minimize the risk of adverse effects. Follow these guidelines for correct usage:
Application Instructions
- Apply a thin layer of the gel directly to the affected area
- Gently massage the gel into the skin over the affected area until it is absorbed
- Wash your hands well after using the gel, unless you are treating your hands
Frequency of Use
Your doctor will tell you how often to use the gel, which is typically three or four times a day. The dosage directions will also be printed on the label of the pack as a reminder of your healthcare provider’s instructions.
If You Forget a Dose
If you forget to apply the gel at your usual time, simply apply it when you remember and then continue as normal. Do not double up on doses to make up for a missed application.
Areas to Avoid
Do not rub your medication into damaged skin, such as wounds, scratches, infections, or areas affected by dermatitis. Additionally, do not apply piroxicam gel near your eyes, nose, mouth, genital, or anal areas, as these are sensitive regions that may be irritated by the medication.
Possible Side Effects
Like all medicines, piroxicam gel can cause side effects in some people. Most side effects are mild and temporary, but it is important to be aware of them and know when to seek medical advice.
Common Side Effects
Mild skin irritation, such as redness or itching, may occur at the application site. This should typically clear within a day or two. If it continues or becomes worse, speak with your doctor as soon as possible.
Skin rash is another potential side effect. If you develop a rash, stop using the gel immediately and contact your doctor.
Serious Side Effects
Stop using the gel and seek medical attention immediately if you experience:
- Breathing difficulties: If you have asthma, symptoms such as wheeze or breathlessness can be worsened by piroxicam. Stop the medication and consult a doctor without delay
- Elevated blood pressure
- Increased risk of bleeding, particularly if you have a history of bleeding disorders
- Impaired kidney function or worsening of existing kidney problems
- Liver damage or liver failure
- Increased sensitivity to sunlight (photosensitivity)
- Blurred vision or other changes in vision
If you experience any other symptoms that you think may be due to the gel, speak with your doctor or pharmacist for further advice.
Precautions and Special Considerations
Piroxicam gel can cause your skin to become more sensitive to sunlight than normal. Protect your skin from bright sunlight during treatment by wearing protective clothing or applying sunscreen to treated areas when possible. This precaution is particularly important during summer months or when spending extended time outdoors.
Before starting treatment, read the manufacturer’s printed information leaflet included in the pack. It will provide comprehensive information about piroxicam and a complete list of potential side effects you could experience from using it.
Comparison with Other Pain Relief Options
Piroxicam gel differs from other topical pain relief options in several ways. While both piroxicam gel and ibuprofen gel work by inhibiting prostaglandin production, they contain different active ingredients. Piroxicam gel is available as a prescription-only medication, whereas ibuprofen gel is often available over the counter. Some studies suggest that piroxicam gel may provide longer-lasting pain relief compared to ibuprofen gel, though research comparing the two medications is limited.
The choice between piroxicam gel and other NSAIDs depends on your medical history, the specific condition you are treating, and the advice of your pharmacist or doctor. Topical NSAIDs like piroxicam offer significant advantages over oral versions because they deliver medication directly to the affected area with minimal systemic absorption, resulting in fewer whole-body side effects.
Frequently Asked Questions
Q: Is piroxicam good for pain?
A: Yes, piroxicam gel is a clinically-effective pain reliever belonging to the NSAID class of drugs. It is best suited for treating conditions involving inflammation or swelling, such as arthritis, sprains, strains, and other joint or muscle pain. However, if you’re experiencing different types of pain, such as migraines, sore throats, or toothaches, paracetamol may be more appropriate.
Q: How long does piroxicam gel take to work?
A: Piroxicam gel begins absorbing through the skin upon application, with the active ingredient penetrating deeper tissues where inflammation occurs. The onset of relief varies depending on the individual and the condition being treated. If there is no improvement in your symptoms after consistent use, inform your doctor.
Q: Can children use piroxicam gel?
A: No, topical anti-inflammatories like piroxicam are prescribed for adults and are not generally suitable for use by children. Always consult with your healthcare provider about appropriate pain relief options for children.
Q: What should I do if I have an allergic reaction to piroxicam gel?
A: If you have ever had an allergic reaction to a non-steroidal painkiller such as aspirin, ibuprofen, diclofenac, or indometacin, inform your doctor before using piroxicam gel. If you experience signs of an allergic reaction while using the gel, stop using it immediately and seek medical attention.
Q: Can I use piroxicam gel if I’m pregnant or breastfeeding?
A: It is important to inform your doctor if you are pregnant or breastfeeding before using piroxicam gel. Your healthcare provider will assess the risks and benefits to determine whether this medication is appropriate for your situation.
Q: How should I store piroxicam gel?
A: Store piroxicam gel according to the instructions provided in the manufacturer’s information leaflet included with your medication. Generally, medicines should be kept in a cool, dry place away from direct sunlight and out of reach of children.
References
- Piroxicam Gel for Pain Relief – Feldene — Patient.info. Last updated 27 Feb 2023. https://patient.info/medicine/piroxicam-gel-for-pain-relief-feldene
- Piroxicam (Feldene): Uses, Side Effects, Interactions — WebMD. https://www.webmd.com/drugs/2/drug-10963/feldene-oral/details
- Piroxicam: Uses, Interactions, Mechanism of Action — DrugBank. https://go.drugbank.com/drugs/DB00554
- Piroxicam (Oral Route) – Side Effects & Dosage — Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/piroxicam-oral-route/description/drg-20069771
- Piroxicam: MedlinePlus Drug Information — MedlinePlus. https://medlineplus.gov/druginfo/meds/a684045.html
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