Why Can’t I Get Pregnant? Understanding Infertility
Explore the causes, diagnosis, and treatment options for infertility with expert insights from Johns Hopkins Medicine.

Why Can’t I Get Pregnant?
Infertility is a common challenge faced by many couples trying to conceive. According to the Centers for Disease Control and Prevention (CDC), about 12% of women aged 15–44 in the United States have difficulty getting pregnant or carrying a pregnancy to term1. Infertility is defined as the inability to conceive after at least 12 months of regular, unprotected intercourse. For women over 35, this period is shortened to six months due to age-related declines in fertility.
What Causes Infertility?
Infertility can result from a variety of factors affecting either partner or both. The causes are often categorized into male, female, and unexplained infertility.
Male Infertility
- Sperm Count and Motility: Low sperm count or poor sperm motility can make conception difficult.
- Testosterone Levels: Abnormal testosterone levels can affect sperm production.
- Genital Abnormalities: Structural issues in the male reproductive system can hinder fertility.
- Lifestyle Factors: Smoking, excessive alcohol consumption, and obesity can negatively impact sperm quality.
Female Infertility
- Ovulation Disorders: Conditions like polycystic ovary syndrome (PCOS) can disrupt ovulation.
- Tubal Factors: Blocked or damaged fallopian tubes can prevent the egg from meeting the sperm.
- Endometriosis: This condition can affect the uterus and fallopian tubes, making conception difficult.
- Uterine Issues: Fibroids, polyps, or other uterine abnormalities can interfere with implantation.
- Age: Fertility declines with age, especially after 35.
Unexplained Infertility
In some cases, no specific cause can be identified despite thorough testing. This is known as unexplained infertility and accounts for about 10–30% of infertility cases2.
Diagnosing Infertility
Diagnosing infertility involves a comprehensive evaluation of both partners. The process typically includes:
For Men
- Semen analysis to assess sperm count, motility, and morphology.
- Blood tests to check hormone levels.
- Physical examination to identify any structural abnormalities.
For Women
- Blood tests to evaluate hormone levels and ovulation.
- Ultrasound to examine the uterus and ovaries.
- Hysterosalpingography (HSG) to check for blocked fallopian tubes.
- Laparoscopy to diagnose endometriosis or other pelvic issues.
Treatment Options for Infertility
Advances in medical science have led to a variety of treatments for infertility. The choice of treatment depends on the underlying cause and the individual’s preferences.
Assisted Reproductive Technologies (ART)
ART includes all treatments that involve the handling of eggs and sperm and/or embryos. Common ART procedures include:
- In Vitro Fertilization (IVF): Eggs are retrieved from the ovaries and fertilized with sperm in a lab. The resulting embryos are then transferred to the uterus.
- Intracytoplasmic Sperm Injection (ICSI): A single sperm is injected directly into an egg to facilitate fertilization.
- Donor Eggs or Sperm: Used when one partner cannot produce viable eggs or sperm.
- Cryopreservation: Eggs, sperm, or embryos are frozen for future use.
Other Treatments
- Medications: Hormonal treatments to stimulate ovulation.
- Surgery: To correct structural issues in the reproductive system.
- Lifestyle Changes: Improving diet, exercise, and reducing stress can enhance fertility.
Support and Counseling
Infertility can be emotionally challenging. Many fertility centers, including Johns Hopkins, offer counseling and support groups to help patients cope with the stress and anxiety associated with infertility and its treatment.
Frequently Asked Questions (FAQs)
Q: How long should I try to conceive before seeking help?
A: If you are under 35, try for at least 12 months. If you are over 35, seek help after 6 months of trying.
Q: Can lifestyle changes improve fertility?
A: Yes, maintaining a healthy weight, eating a balanced diet, exercising regularly, and avoiding smoking and excessive alcohol can improve fertility.
Q: What are the success rates of IVF?
A: Success rates vary by age and individual factors. For women under 35, the success rate is about 25–30%. For women over 40, it drops to around 5–10%3.
Q: Is infertility only a woman’s problem?
A: No, infertility can affect both men and women. About one-third of infertility cases are due to male factors, one-third to female factors, and one-third to a combination of both or unexplained causes.
References
- Infertility and Women’s Health — Centers for Disease Control and Prevention. 2023. https://www.cdc.gov/reproductivehealth/infertility/index.htm
- Unexplained Infertility — American Society for Reproductive Medicine. 2022. https://www.asrm.org/topics/topics-index/unexplained-infertility/
- IVF Success Rates — Society for Assisted Reproductive Technology. 2023. https://www.sart.org/patient-resources/success-rates/
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